Cargando…

Host HLA B*Allele-Associated Multi-Clade Gag T-Cell Recognition Correlates with Slow HIV-1 Disease Progression in Antiretroviral Therapy-Naïve Ugandans

BACKGROUND: Some HIV infected individuals remain asymptomatic for protracted periods of time in the absence of antiretroviral therapy (ART). Virological control, CD4 T cell loss and HIV-specific responses are some of the key interrelated determinants of HIV-1 disease progression. In this study, poss...

Descripción completa

Detalles Bibliográficos
Autores principales:	Serwanga, Jennifer, Shafer, Leigh Anne, Pimego, Edward, Auma, Betty, Watera, Christine, Rowland, Samantha, Yirrell, David, Pala, Pietro, Grosskurth, Heiner, Whitworth, Jimmy, Gotch, Frances, Kaleebu, Pontiano
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2617765/ https://www.ncbi.nlm.nih.gov/pubmed/19142234 http://dx.doi.org/10.1371/journal.pone.0004188

Ejemplares similares

CD8(+) T-Cell Responses before and after Structured Treatment Interruption in Ugandan Adults Who Initiated ART with CD4(+) T Cells <200 Cell/μL: The DART Trial STI Substudy
por: Serwanga, Jennifer, et al.
Publicado: (2011)

P20-10. Differences in patterns of Gag-induced immunogenetic pressure occur between clades A and D chronic HIV-1 infection in a Ugandan population
por: Serwanga, J, et al.
Publicado: (2009)

Frequencies of Gag-restricted T-cell escape “footprints” differ across HIV-1 clades A1 and D chronically infected Ugandans irrespective of host HLA B alleles()
por: Serwanga, Jennifer, et al.
Publicado: (2015)

Computational MHC-I epitope predictor identifies 95% of experimentally mapped HIV-1 clade A and D epitopes in a Ugandan cohort
por: Bugembe, Daniel Lule, et al.
Publicado: (2020)

P16-03. Persistence of robust cross-reactive group M consensus T-cell responses in a chronic HIV-1 clade A1 and D-infected Ugandan population
por: Serwanga, JJ, et al.
Publicado: (2009)

Coreceptor and Cytokine Concentrations May Not Explain Differences in Disease Progression Observed in HIV-1 Clade A and D Infected Ugandans
por: Wright, Edward, et al.
Publicado: (2011)

Effect of Stopping Cotrimoxazole Preventive Therapy on Microbial Translocation and Inflammatory Markers Among Human Immunodeficiency Virus–Infected Ugandan Adults on Antiretroviral Therapy: The COSTOP Trial Immunology Substudy
por: Kyosiimire-Lugemwa, Jacqueline, et al.
Publicado: (2020)

Seroprevalence and durability of antibody responses to AstraZeneca vaccination in Ugandans with prior mild or asymptomatic COVID-19: implications for vaccine policy
por: Serwanga, Jennifer, et al.
Publicado: (2023)

Interferon gamma (IFN-γ) negative CD4+ and CD8+ T-cells can produce immune mediators in response to viral antigens
por: Nakiboneka, Ritah, et al.
Publicado: (2019)

P16-16. Gag and Nef specific T-cell responses in HIV-1 infected long-term non-progressors in Uganda
por: Kyosiimire-Lugemwa, J, et al.
Publicado: (2009)

Effect of HIV-1 Subtypes on Disease Progression in Rural Uganda: A Prospective Clinical Cohort Study
por: Ssemwanga, Deogratius, et al.
Publicado: (2013)

HIV-1 Gag-Pol Sequences from Ugandan Early Infections Reveal Sequence Variants Associated with Elevated Replication Capacity
por: Kapaata, Anne, et al.
Publicado: (2021)

Vaccination against SARS-CoV-2 in a rural Ugandan population
por: Mugisha, Joseph, et al.
Publicado: (2023)

Effect of antiretroviral therapy on malaria incidence in HIV-infected Ugandan adults
por: Kasirye, Ronnie P., et al.
Publicado: (2017)

P04-11. Prevalence of neutralizing antibody responses in chronic clades A and D human immunodeficiency virus type 1 (HIV-1) infections
por: Njai, HF, et al.
Publicado: (2009)

Readiness of Ugandan health services for the management of outpatients with chronic diseases
por: Katende, David, et al.
Publicado: (2015)

Cardiometabolic risk among HIV-POSITIVE Ugandan adults: prevalence, predictors and effect of long-term antiretroviral therapy
por: Kazooba, Patrick, et al.
Publicado: (2017)

The effect of Tenofovir on renal function among Ugandan adults on long-term antiretroviral therapy: a cross-sectional enrolment analysis
por: Salome, Tino, et al.
Publicado: (2016)

Pre-pandemic SARS-CoV-2-specific IFN-γ and antibody responses were low in Ugandan samples and significantly reduced in HIV-positive specimens
por: Nantambi, Hellen, et al.
Publicado: (2023)

HIV specific Th1 responses are altered in Ugandans with HIV and Schistosoma mansoni coinfection
por: Obuku, Andrew Ekii, et al.
Publicado: (2023)

Investigating the non-specific effects of BCG vaccination on the innate immune system in Ugandan neonates: study protocol for a randomised controlled trial
por: Prentice, Sarah, et al.
Publicado: (2015)

Correction to: Investigating the non-specific effects of BCG vaccination on the innate immune system in Ugandan neonates: study protocol for a randomised controlled trial
por: Prentice, Sarah, et al.
Publicado: (2020)

Safety and Immunogenicity of a 2-Dose Heterologous Vaccination Regimen With Ad26.ZEBOV and MVA-BN-Filo Ebola Vaccines: 12-Month Data From a Phase 1 Randomized Clinical Trial in Uganda and Tanzania
por: Anywaine, Zacchaeus, et al.
Publicado: (2019)

Rapid, early, and potent Spike-directed IgG, IgM, and IgA distinguish asymptomatic from mildly symptomatic COVID-19 in Uganda, with IgG persisting for 28 months
por: Serwanga, Jennifer, et al.
Publicado: (2023)

Multiple HIV-1 infections with evidence of recombination in heterosexual partnerships in a low risk Rural Clinical Cohort in Uganda
por: Ssemwanga, Deogratius, et al.
Publicado: (2011)

Effect of Schistosoma mansoni Infection on Innate and HIV-1-Specific T-Cell Immune Responses in HIV-1-Infected Ugandan Fisher Folk
por: Obuku, Andrew Ekii, et al.
Publicado: (2016)

Incidence of malaria by cotrimoxazole use in HIV-infected Ugandan adults on antiretroviral therapy: a randomised, placebo-controlled study
por: Kasirye, Ronnie P., et al.
Publicado: (2016)

Killer cell immunoglobulin-like receptor (KIR) genes and their HLA-C ligands in a Ugandan population
por: Nakimuli, Annettee, et al.
Publicado: (2013)

Optimization and validation of an ELISA assay for the determination of antibody responses to CN54gp140 and AIDSVAX BE for use in the Phase IIb PrEPVacc vaccine trial
por: Gombe, Ben, et al.
Publicado: (2022)

Analysis of Ugandan cervical carcinomas identifies human papillomavirus clade-specific epigenome and transcriptome landscapes.
por: Gagliardi, Alessia, et al.
Publicado: (2020)

From antiretroviral therapy access to provision of third line regimens: evidence of HIV Drug resistance mutations to first and second line regimens among Ugandan adults
por: Namakoola, Ivan, et al.
Publicado: (2016)

Longitudinal effect of CD4 by cotrimoxazole use on malaria incidence among HIV-infected Ugandan adults on antiretroviral therapy: a randomized controlled study
por: Kasirye, Ronnie, et al.
Publicado: (2016)

Evaluation of the performance of 25 SARS-CoV-2 serological rapid diagnostic tests using a reference panel of plasma specimens at the Uganda Virus Research Institute
por: Lutalo, Tom, et al.
Publicado: (2021)

Poor immunological recovery among severely immunosuppressed antiretroviral therapy-naïve Ugandans
por: Nanzigu, Sarah, et al.
Publicado: (2013)

Phylogeography of HIV-1 suggests that Ugandan fishing communities are a sink for, not a source of, virus from general populations
por: Bbosa, Nicholas, et al.
Publicado: (2019)

Population-based monitoring of HIV drug resistance early warning indicators in Uganda: A nationally representative survey following revised WHO recommendations
por: Asio, Juliet, et al.
Publicado: (2020)

Optimisation and Validation of a conventional ELISA and cut-offs for detecting and quantifying anti-SARS-CoV-2 Spike, RBD, and Nucleoprotein IgG, IgM, and IgA antibodies in Uganda
por: Oluka, Gerald Kevin, et al.
Publicado: (2023)

Gender, violence and resilience among Ugandan adolescents
por: Namy, Sophie, et al.
Publicado: (2017)

New insights into retroviral Gag–Gag and Gag–membrane interactions
por: Maldonado, José O., et al.
Publicado: (2014)

Gag-Protease Sequence Evolution Following Protease Inhibitor Monotherapy Treatment Failure in HIV-1 Viruses Circulating in East Africa
por: Sutherland, Katherine A., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_l8s4dprbr7og50gg2n7chr3v3l