Recombinant Mouse PAP Has pH-Dependent Ectonucleotidase Activity and Acts through A(1)-Adenosine Receptors to Mediate Antinociception

Prostatic acid phosphatase (PAP) is expressed in nociceptive neurons and functions as an ectonucleotidase. When injected intraspinally, the secretory isoforms of human and bovine PAP protein have potent and long-lasting antinociceptive effects that are dependent on A(1)-adenosine receptor (A(1)R) ac...

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Detalles Bibliográficos
Autores principales: Sowa, Nathaniel A., Vadakkan, Kunjumon I., Zylka, Mark J.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2617779/
https://www.ncbi.nlm.nih.gov/pubmed/19158948
http://dx.doi.org/10.1371/journal.pone.0004248

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2617779/
https://www.ncbi.nlm.nih.gov/pubmed/19158948
http://dx.doi.org/10.1371/journal.pone.0004248

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