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Recombinant Mouse PAP Has pH-Dependent Ectonucleotidase Activity and Acts through A(1)-Adenosine Receptors to Mediate Antinociception
Prostatic acid phosphatase (PAP) is expressed in nociceptive neurons and functions as an ectonucleotidase. When injected intraspinally, the secretory isoforms of human and bovine PAP protein have potent and long-lasting antinociceptive effects that are dependent on A(1)-adenosine receptor (A(1)R) ac...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2617779/ https://www.ncbi.nlm.nih.gov/pubmed/19158948 http://dx.doi.org/10.1371/journal.pone.0004248 |