The Influence of Catalysis on Mad2 Activation Dynamics

Mad2 is a key component of the spindle assembly checkpoint, a safety device ensuring faithful sister chromatid separation in mitosis. The target of Mad2 is Cdc20, an activator of the anaphase-promoting complex/cyclosome (APC/C). Mad2 binding to Cdc20 is a complex reaction that entails the conformati...

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Detalles Bibliográficos
Autores principales: Simonetta, Marco, Manzoni, Romilde, Mosca, Roberto, Mapelli, Marina, Massimiliano, Lucia, Vink, Martin, Novak, Bela, Musacchio, Andrea, Ciliberto, Andrea
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2621267/
https://www.ncbi.nlm.nih.gov/pubmed/19143472
http://dx.doi.org/10.1371/journal.pbio.1000010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2621267/
https://www.ncbi.nlm.nih.gov/pubmed/19143472
http://dx.doi.org/10.1371/journal.pbio.1000010

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