An ALS-Linked Mutant SOD1 Produces a Locomotor Defect Associated with Aggregation and Synaptic Dysfunction When Expressed in Neurons of Caenorhabditis elegans

The nature of toxic effects exerted on neurons by misfolded proteins, occurring in a number of neurodegenerative diseases, is poorly understood. One approach to this problem is to measure effects when such proteins are expressed in heterologous neurons. We report on effects of an ALS-associated, mis...

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Detalles Bibliográficos
Autores principales: Wang, Jiou, Farr, George W., Hall, David H., Li, Fei, Furtak, Krystyna, Dreier, Lars, Horwich, Arthur L.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2621352/
https://www.ncbi.nlm.nih.gov/pubmed/19165329
http://dx.doi.org/10.1371/journal.pgen.1000350

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2621352/
https://www.ncbi.nlm.nih.gov/pubmed/19165329
http://dx.doi.org/10.1371/journal.pgen.1000350

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