What Does PLIER Really Do?

MOTIVATION: Our goal was to understand why the PLIER algorithm performs so well given its derivation is based on a biologically implausible assumption. RESULTS: In spite of a non-intuitive assumption regarding the PM and MM errors made as part of the derivation for PLIER, the resulting probe level e...

Descripción completa

Detalles Bibliográficos
Autores principales: Therneau, Terry M., Ballman, Karla V.
Formato: Texto
Lenguaje:English
Publicado: Libertas Academica 2008
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2623311/
https://www.ncbi.nlm.nih.gov/pubmed/19259420
_version_ 1782163426052669440
author Therneau, Terry M.
Ballman, Karla V.
author_facet Therneau, Terry M.
Ballman, Karla V.
author_sort Therneau, Terry M.
collection PubMed
description MOTIVATION: Our goal was to understand why the PLIER algorithm performs so well given its derivation is based on a biologically implausible assumption. RESULTS: In spite of a non-intuitive assumption regarding the PM and MM errors made as part of the derivation for PLIER, the resulting probe level error function does capture the key characteristics of the ideal error function, assuming MM probes only measure non-specific binding and no signal.
format Text
id pubmed-2623311
institution National Center for Biotechnology Information
language English
publishDate 2008
publisher Libertas Academica
record_format MEDLINE/PubMed
spelling pubmed-26233112009-02-24 What Does PLIER Really Do? Therneau, Terry M. Ballman, Karla V. Cancer Inform Original Article MOTIVATION: Our goal was to understand why the PLIER algorithm performs so well given its derivation is based on a biologically implausible assumption. RESULTS: In spite of a non-intuitive assumption regarding the PM and MM errors made as part of the derivation for PLIER, the resulting probe level error function does capture the key characteristics of the ideal error function, assuming MM probes only measure non-specific binding and no signal. Libertas Academica 2008-08-27 /pmc/articles/PMC2623311/ /pubmed/19259420 Text en © 2008 by the authors http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Original Article
Therneau, Terry M.
Ballman, Karla V.
What Does PLIER Really Do?
title What Does PLIER Really Do?
title_full What Does PLIER Really Do?
title_fullStr What Does PLIER Really Do?
title_full_unstemmed What Does PLIER Really Do?
title_short What Does PLIER Really Do?
title_sort what does plier really do?
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2623311/
https://www.ncbi.nlm.nih.gov/pubmed/19259420
work_keys_str_mv AT therneauterrym whatdoesplierreallydo
AT ballmankarlav whatdoesplierreallydo

Ejemplares similares