Flexible modulation of agonist efficacy at the human A(3 )adenosine receptor by the imidazoquinoline allosteric enhancer LUF6000

BACKGROUND: A series of 1H-imidazo- [4,5-c]quinolin-4-amine derivatives, represented by LUF6000 (N-(3,4-dichloro-phenyl)-2-cyclohexyl-1H-imidazo [4,5-c]quinolin-4-amine), are allosteric modulators of the human A(3 )adenosine receptor (AR). Here we studied the modulation by LUF6000 of the maximum eff...

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Detalles Bibliográficos
Autores principales: Gao, Zhan-Guo, Ye, Kai, Göblyös, Anikó, IJzerman, Adriaan P, Jacobson, Kenneth A
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2625337/
https://www.ncbi.nlm.nih.gov/pubmed/19077268
http://dx.doi.org/10.1186/1471-2210-8-20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2625337/
https://www.ncbi.nlm.nih.gov/pubmed/19077268
http://dx.doi.org/10.1186/1471-2210-8-20

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