Down-regulation of CYLD expression by Snail promotes tumor progression in malignant melanoma

High malignancy and early metastasis are hallmarks of melanoma. Here, we report that the transcription factor Snail1 inhibits expression of the tumor suppressor CYLD in melanoma. As a direct consequence of CYLD repression, the protooncogene BCL-3 translocates into the nucleus and activates Cyclin D1...

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Detalles Bibliográficos
Autores principales: Massoumi, Ramin, Kuphal, Silke, Hellerbrand, Claus, Haas, Bodo, Wild, Peter, Spruss, Thilo, Pfeifer, Alexander, Fässler, Reinhard, Bosserhoff, Anja K.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2626666/
https://www.ncbi.nlm.nih.gov/pubmed/19124656
http://dx.doi.org/10.1084/jem.20082044

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2626666/
https://www.ncbi.nlm.nih.gov/pubmed/19124656
http://dx.doi.org/10.1084/jem.20082044

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