Runx3 and T-box proteins cooperate to establish the transcriptional program of effector CTLs

Activation of naive CD8(+) T cells with antigen induces their differentiation into effector cytolytic T lymphocytes (CTLs). CTLs lyse infected or aberrant target cells by exocytosis of lytic granules containing the pore-forming protein perforin and a family of proteases termed granzymes. We show tha...

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Detalles Bibliográficos
Autores principales: Cruz-Guilloty, Fernando, Pipkin, Matthew E., Djuretic, Ivana M., Levanon, Ditsa, Lotem, Joseph, Lichtenheld, Mathias G., Groner, Yoram, Rao, Anjana
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Brief Definitive Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2626671/
https://www.ncbi.nlm.nih.gov/pubmed/19139168
http://dx.doi.org/10.1084/jem.20081242

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2626671/
https://www.ncbi.nlm.nih.gov/pubmed/19139168
http://dx.doi.org/10.1084/jem.20081242

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