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A role for the IgH intronic enhancer Eμ in enforcing allelic exclusion
The intronic enhancer (Eμ) of the immunoglobulin heavy chain (IgH) locus is critical for V region gene assembly. To determine Eμ's subsequent functions, we created an Igh allele with assembled V(H) gene but with Eμ removed. In mice homozygous for this Eμ-deficient allele, B cell development was...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2626684/ https://www.ncbi.nlm.nih.gov/pubmed/19114667 http://dx.doi.org/10.1084/jem.20081202 |