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A role for the IgH intronic enhancer Eμ in enforcing allelic exclusion

The intronic enhancer (Eμ) of the immunoglobulin heavy chain (IgH) locus is critical for V region gene assembly. To determine Eμ's subsequent functions, we created an Igh allele with assembled V(H) gene but with Eμ removed. In mice homozygous for this Eμ-deficient allele, B cell development was...

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Detalles Bibliográficos
Autores principales:	Li, Fubin, Eckhardt, Laurel A.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2009
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2626684/ https://www.ncbi.nlm.nih.gov/pubmed/19114667 http://dx.doi.org/10.1084/jem.20081202

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