α-Methylprednisolone conjugated cyclodextrin polymer-based nanoparticles for rheumatoid arthritis therapy

A glycinate derivative of α-methylprednisolone (MP) was prepared and conjugated to a linear cyclodextrin polymer (CDP) with a loading of 12.4% w/w. The polymer conjugate (CDP-MP) self-assembled into nanoparticles with a size of 27 nm. Release kinetics of MP from the polymer conjugate showed a half-l...

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Detalles Bibliográficos
Autores principales: Hwang, Jungyeon, Rodgers, Kathleen, Oliver, James C, Schluep, Thomas
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2008
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2626937/
https://www.ncbi.nlm.nih.gov/pubmed/18990945

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2626937/
https://www.ncbi.nlm.nih.gov/pubmed/18990945

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