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Computational Fitness Landscape for All Gene-Order Permutations of an RNA Virus
How does the growth of a virus depend on the linear arrangement of genes in its genome? Answering this question may enhance our basic understanding of virus evolution and advance applications of viruses as live attenuated vaccines, gene-therapy vectors, or anti-tumor therapeutics. We used a mathemat...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2627932/ https://www.ncbi.nlm.nih.gov/pubmed/19197345 http://dx.doi.org/10.1371/journal.pcbi.1000283 |