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Derangement of a Factor Upstream of RARα Triggers the Repression of a Pleiotropic Epigenetic Network

BACKGROUND: Chromatin adapts and responds to extrinsic and intrinsic cues. We hypothesize that inheritable aberrant chromatin states in cancer and aging are caused by genetic/environmental factors. In previous studies we demonstrated that either genetic mutations, or loss, of retinoic acid receptor...

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Detalles Bibliográficos
Autores principales: Corlazzoli, Francesca, Rossetti, Stefano, Bistulfi, Gaia, Ren, Mingqiang, Sacchi, Nicoletta
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2627936/
https://www.ncbi.nlm.nih.gov/pubmed/19173001
http://dx.doi.org/10.1371/journal.pone.0004305