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Short Telomeres Initiate Telomere Recombination in Primary and Tumor Cells

Human tumors that lack telomerase maintain telomeres by alternative lengthening mechanisms. Tumors can also form in telomerase-deficient mice; however, the genetic mechanism responsible for tumor growth without telomerase is unknown. In yeast, several different recombination pathways maintain telome...

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Detalles Bibliográficos
Autores principales: Morrish, Tammy A., Greider, Carol W.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2627939/
https://www.ncbi.nlm.nih.gov/pubmed/19180191
http://dx.doi.org/10.1371/journal.pgen.1000357