Graded Smad2/3 Activation Is Converted Directly into Levels of Target Gene Expression in Embryonic Stem Cells

The Transforming Growth Factor (TGF) β signalling family includes morphogens, such as Nodal and Activin, with important functions in vertebrate development. The concentration of the morphogen is critical for fate decisions in the responding cells. Smad2 and Smad3 are effectors of the Nodal/Activin b...

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Detalles Bibliográficos
Autores principales: Guzman-Ayala, Marcela, Lee, Kian Leong, Mavrakis, Konstantinos J., Goggolidou, Paraskevi, Norris, Dominic P., Episkopou, Vasso
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2627943/
https://www.ncbi.nlm.nih.gov/pubmed/19172185
http://dx.doi.org/10.1371/journal.pone.0004268

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2627943/
https://www.ncbi.nlm.nih.gov/pubmed/19172185
http://dx.doi.org/10.1371/journal.pone.0004268

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