Role of a Novel PH-Kinase Domain Interface in PKB/Akt Regulation: Structural Mechanism for Allosteric Inhibition

Protein kinase B (PKB/Akt) belongs to the AGC superfamily of related serine/threonine protein kinases. It is a key regulator downstream of various growth factors and hormones and is involved in malignant transformation and chemo-resistance. Full-length PKB protein has not been crystallised, thus stu...

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Detalles Bibliográficos
Autores principales: Calleja, Véronique, Laguerre, Michel, Parker, Peter J, Larijani, Banafshé
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628406/
https://www.ncbi.nlm.nih.gov/pubmed/19166270
http://dx.doi.org/10.1371/journal.pbio.1000017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628406/
https://www.ncbi.nlm.nih.gov/pubmed/19166270
http://dx.doi.org/10.1371/journal.pbio.1000017

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