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Role of a Novel PH-Kinase Domain Interface in PKB/Akt Regulation: Structural Mechanism for Allosteric Inhibition

Protein kinase B (PKB/Akt) belongs to the AGC superfamily of related serine/threonine protein kinases. It is a key regulator downstream of various growth factors and hormones and is involved in malignant transformation and chemo-resistance. Full-length PKB protein has not been crystallised, thus stu...

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Detalles Bibliográficos
Autores principales:	Calleja, Véronique, Laguerre, Michel, Parker, Peter J, Larijani, Banafshé
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628406/ https://www.ncbi.nlm.nih.gov/pubmed/19166270 http://dx.doi.org/10.1371/journal.pbio.1000017

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