Catalytic inhibition of topoisomerase II by a novel rationally designed ATP-competitive purine analogue

BACKGROUND: Topoisomerase II poisons are in clinical use as anti-cancer therapy for decades and work by stabilizing the enzyme-induced DNA breaks. In contrast, catalytic inhibitors block the enzyme before DNA scission. Although several catalytic inhibitors of topoisomerase II have been described, pr...

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Detalles Bibliográficos
Autores principales: Chène, Patrick, Rudloff, Joëlle, Schoepfer, Joseph, Furet, Pascal, Meier, Peter, Qian, Zhiyan, Schlaeppi, Jean-Marc, Schmitz, Rita, Radimerski, Thomas
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628638/
https://www.ncbi.nlm.nih.gov/pubmed/19128485
http://dx.doi.org/10.1186/1472-6769-9-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628638/
https://www.ncbi.nlm.nih.gov/pubmed/19128485
http://dx.doi.org/10.1186/1472-6769-9-1

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