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Catalytic inhibition of topoisomerase II by a novel rationally designed ATP-competitive purine analogue
BACKGROUND: Topoisomerase II poisons are in clinical use as anti-cancer therapy for decades and work by stabilizing the enzyme-induced DNA breaks. In contrast, catalytic inhibitors block the enzyme before DNA scission. Although several catalytic inhibitors of topoisomerase II have been described, pr...
| Autores principales: | , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628638/ https://www.ncbi.nlm.nih.gov/pubmed/19128485 http://dx.doi.org/10.1186/1472-6769-9-1 |