Cargando…

Complex nature of SNP genotype effects on gene expression in primary human leucocytes

BACKGROUND: Genome wide association studies have been hugely successful in identifying disease risk variants, yet most variants do not lead to coding changes and how variants influence biological function is usually unknown. METHODS: We correlated gene expression and genetic variation in untouched p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Heap, Graham A, Trynka, Gosia, Jansen, Ritsert C, Bruinenberg, Marcel, Swertz, Morris A, Dinesen, Lotte C, Hunt, Karen A, Wijmenga, Cisca, vanHeel, David A, Franke, Lude
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628677/ https://www.ncbi.nlm.nih.gov/pubmed/19128478 http://dx.doi.org/10.1186/1755-8794-2-1

Ejemplares similares

No Evidence in a Large UK Collection for Celiac Disease Risk Variants Reported by a Spanish Study
por: Hunt, Karen A., et al.
Publicado: (2008)

Ciliary Genes Are Down-Regulated in Bronchial Tissue of Primary Ciliary Dyskinesia Patients
por: Geremek, Maciej, et al.
Publicado: (2014)

Evaluation of European coeliac disease risk variants in a north Indian population
por: Senapati, Sabyasachi, et al.
Publicado: (2015)

Fine-mapping in the MHC region accounts for 18% additional genetic risk for celiac disease
por: Gutierrez-Achury, Javier, et al.
Publicado: (2015)

Lack of Association Between Genetic Variants at ACE2 and TMPRSS2 Genes Involved in SARS-CoV-2 Infection and Human Quantitative Phenotypes
por: Lopera Maya, Esteban A., et al.
Publicado: (2020)

Co-expressed immune and metabolic genes in visceral and subcutaneous adipose tissue from severely obese individuals are associated with plasma HDL and glucose levels: a microarray study
por: Wolfs, Marcel GM, et al.
Publicado: (2010)

Calling genotypes from public RNA-sequencing data enables identification of genetic variants that affect gene-expression levels
por: Deelen, Patrick, et al.
Publicado: (2015)

Fine mapping of the celiac disease-associated LPP locus reveals a potential functional variant
por: Almeida, Rodrigo, et al.
Publicado: (2014)

Trans-eQTLs Reveal That Independent Genetic Variants Associated with a Complex Phenotype Converge on Intermediate Genes, with a Major Role for the HLA
por: Fehrmann, Rudolf S. N., et al.
Publicado: (2011)

Habitual dietary intake of IBD patients differs from population controls: a case–control study
por: Peters, Vera, et al.
Publicado: (2020)

designGG: an R-package and web tool for the optimal design of genetical genomics experiments
por: Li, Yang, et al.
Publicado: (2009)

Unraveling the Regulatory Mechanisms Underlying Tissue-Dependent Genetic Variation of Gene Expression
por: Fu, Jingyuan, et al.
Publicado: (2012)

Improving coeliac disease risk prediction by testing non-HLA variants additional to HLA variants
por: Romanos, Jihane, et al.
Publicado: (2014)

The influence of a short-term gluten-free diet on the human gut microbiome
por: Bonder, Marc Jan, et al.
Publicado: (2016)

Cohort profile: LifeLines DEEP, a prospective, general population cohort study in the northern Netherlands: study design and baseline characteristics
por: Tigchelaar, Ettje F, et al.
Publicado: (2015)

GAVIN: Gene-Aware Variant INterpretation for medical sequencing
por: van der Velde, K. Joeri, et al.
Publicado: (2017)

Genotype harmonizer: automatic strand alignment and format conversion for genotype data integration
por: Deelen, Patrick, et al.
Publicado: (2014)

A Meta-Analysis of Genome-Wide Association Scans Identifies IL18RAP, PTPN2, TAGAP, and PUS10 As Shared Risk Loci for Crohn's Disease and Celiac Disease
por: Festen, Eleonora A. M., et al.
Publicado: (2011)

Semi-automatic translation of medicine usage data (in Dutch, free-text) from Lifelines COVID-19 questionnaires to ATC codes
por: Kellmann, Alexander J, et al.
Publicado: (2023)

Worm variation made accessible: Take your shopping cart to store, link, and investigate!
por: Snoek, L Basten, et al.
Publicado: (2014)

Functional studies of GWAS variants are gaining momentum
por: Lichou, Florence, et al.
Publicado: (2020)

snpEnrichR: analyzing co-localization of SNPs and their proxies in genomic regions
por: Nousiainen, Kari, et al.
Publicado: (2018)

Immunogenomic approaches to understand the function of immune disease variants
por: Glinos, Dafni A., et al.
Publicado: (2017)

xQTL workbench: a scalable web environment for multi-level QTL analysis
por: Arends, Danny, et al.
Publicado: (2012)

Eosinophil Count Is a Common Factor for Complex Metabolic and Pulmonary Traits and Diseases: The LifeLines Cohort Study
por: Amini, Marzyeh, et al.
Publicado: (2016)

From GWAS to Function: Using Functional Genomics to Identify the Mechanisms Underlying Complex Diseases
por: Cano-Gamez, Eddie, et al.
Publicado: (2020)

Variants in Neuropeptide Y Receptor 1 and 5 Are Associated with Nutrient-Specific Food Intake and Are Under Recent Selection in Europeans
por: Elbers, Clara C., et al.
Publicado: (2009)

Single-cell RNA sequencing identifies cell type-specific cis-eQTLs and co-expression QTLs
por: van der Wijst, Monique G.P., et al.
Publicado: (2018)

reGenotyper: Detecting mislabeled samples in genetic data
por: Zych, Konrad, et al.
Publicado: (2017)

Expressing the Differences between Crohn Disease and Ulcerative Colitis
por: Wijmenga, Cisca
Publicado: (2005)

Bioinformatics tools and database resources for systems genetics analysis in mice—a short review and an evaluation of future needs
por: Durrant, Caroline, et al.
Publicado: (2012)

WormQTL(HD)—a web database for linking human disease to natural variation data in C. elegans
por: van der Velde, K. Joeri, et al.
Publicado: (2014)

Genome-wide analysis of allelic expression imbalance in human primary cells by high-throughput transcriptome resequencing
por: Heap, Graham A., et al.
Publicado: (2010)

Contrasting the Genetic Background of Type 1 Diabetes and Celiac Disease Autoimmunity
por: Gutierrez-Achury, Javier, et al.
Publicado: (2015)

Leucocyte function
por: Matera, Lina
Publicado: (1983)

LEUCOCYTIC SECRETIONS
por: Carrel, Alexis, et al.
Publicado: (1922)

The Leucocyte in Disease
por: Jones, H. S. Wansbrough
Publicado: (1896)

Characterization of gangliosides in human leucocytes.
por: Tsuboyama, A., et al.
Publicado: (1980)

A SNP panel for identification of DNA and RNA specimens
por: Yousefi, Soheil, et al.
Publicado: (2018)

The Leucocyte Count in Weil's Disease
por: Kennedy, C. Cotton
Publicado: (1958)

Cannot write session to /tmp/vufind_sessions/sess_td6e4q2ih1p05697er2maoat67