Crystallization and preliminary X-ray diffraction analysis of the complex between a human anti-interferon antibody fragment and human interferon α-2A

Recombinant human interferon α-2A (rhIFN-α-2A) has been crystallized in complex with the recombinantly produced Fab fragment of a therapeutic monoclonal antibody (MEDI545; IgG1/κ) which targets several human inter­feron α subtypes. This constitutes the first reported crystals of a human type I inter...

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Detalles Bibliográficos
Autores principales: Oganesyan, Vaheh, Damschroder, Melissa M., Cook, Kimberly E., Wu, Herren, Dall’Acqua, William F.
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2008
Materias:
Crystallization Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628856/
https://www.ncbi.nlm.nih.gov/pubmed/19153447
http://dx.doi.org/10.1107/S1744309108037925

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628856/
https://www.ncbi.nlm.nih.gov/pubmed/19153447
http://dx.doi.org/10.1107/S1744309108037925

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