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Crystallization and preliminary X-ray diffraction analysis of the complex between a human anti-interferon antibody fragment and human interferon α-2A

Recombinant human interferon α-2A (rhIFN-α-2A) has been crystallized in complex with the recombinantly produced Fab fragment of a therapeutic monoclonal antibody (MEDI545; IgG1/κ) which targets several human interferon α subtypes. This constitutes the first reported crystals of a human type I inter...

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Detalles Bibliográficos
Autores principales:	Oganesyan, Vaheh, Damschroder, Melissa M., Cook, Kimberly E., Wu, Herren, Dall’Acqua, William F.
Formato:	Texto
Lenguaje:	English
Publicado:	International Union of Crystallography 2008
Materias:	Crystallization Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628856/ https://www.ncbi.nlm.nih.gov/pubmed/19153447 http://dx.doi.org/10.1107/S1744309108037925

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