Inhibition of HIF-1alpha activity by homeodomain-interacting protein kinase-2 correlates with sensitization of chemoresistant cells to undergo apoptosis

BACKGROUND: Homeodomain-interacting protein kinase-2 (HIPK2), a transcriptional co-repressor with apoptotic function, can affect hypoxia-inducible factor 1 (HIF-1) transcriptional activity, through downmodulation of its HIF-1α subunit, in normoxic condition. Under hypoxia, a condition often found in...

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Detalles Bibliográficos
Autores principales: Nardinocchi, Lavinia, Puca, Rosa, Sacchi, Ada, D'Orazi, Gabriella
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628864/
https://www.ncbi.nlm.nih.gov/pubmed/19128456
http://dx.doi.org/10.1186/1476-4598-8-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628864/
https://www.ncbi.nlm.nih.gov/pubmed/19128456
http://dx.doi.org/10.1186/1476-4598-8-1

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