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Timing Is Critical for Effective Glucocorticoid Receptor Mediated Repression of the cAMP-Induced CRH Gene

Glucocorticoid negative feedback of the hypothalamus-pituitary-adrenal axis is mediated in part by direct repression of gene transcription in glucocorticoid receptor (GR) expressing cells. We have investigated the cross talk between the two main signaling pathways involved in activation and repressi...

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Detalles Bibliográficos
Autores principales: van der Laan, Siem, de Kloet, E. Ronald, Meijer, Onno C.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2629571/
https://www.ncbi.nlm.nih.gov/pubmed/19177170
http://dx.doi.org/10.1371/journal.pone.0004327