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Timing Is Critical for Effective Glucocorticoid Receptor Mediated Repression of the cAMP-Induced CRH Gene
Glucocorticoid negative feedback of the hypothalamus-pituitary-adrenal axis is mediated in part by direct repression of gene transcription in glucocorticoid receptor (GR) expressing cells. We have investigated the cross talk between the two main signaling pathways involved in activation and repressi...
Autores principales: | van der Laan, Siem, de Kloet, E. Ronald, Meijer, Onno C. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2629571/ https://www.ncbi.nlm.nih.gov/pubmed/19177170 http://dx.doi.org/10.1371/journal.pone.0004327 |
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