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Adult and Embryonic GAD Transcripts Are Spatiotemporally Regulated during Postnatal Development in the Rat Brain

BACKGROUND: GABA (gamma-aminobutyric acid), the main inhibitory neurotransmitter in the brain, is synthesized by glutamic acid decarboxylase (GAD). GAD exists in two adult isoforms, GAD65 and GAD67. During embryonic brain development at least two additional transcripts exist, I-80 and I-86, which ar...

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Detalles Bibliográficos
Autores principales: Popp, Anke, Urbach, Anja, Witte, Otto W., Frahm, Christiane
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2629816/
https://www.ncbi.nlm.nih.gov/pubmed/19190758
http://dx.doi.org/10.1371/journal.pone.0004371