Embryonic Stem Cell Specific MicroRNAs Regulate the G1/S Transition and Promote Rapid Proliferation

Dgcr8 knockout embryonic stem (ES) cells lack microprocessor activity and hence all canonical microRNAs (miRNAs). These cells proliferate slowly and accumulate in G1 phase of the cell cycle1. Here, by screening a comprehensive library of individual miRNAs in the background of the Dgcr8 knockout ES c...

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Detalles Bibliográficos
Autores principales: Wang, Yangming, Baskerville, Scott, Shenoy, Archana, Babiarz, Joshua E, Baehner, Lauren, Blelloch, Robert
Formato: Texto
Lenguaje:English
Publicado: 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2630798/
https://www.ncbi.nlm.nih.gov/pubmed/18978791
http://dx.doi.org/10.1038/ng.250

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2630798/
https://www.ncbi.nlm.nih.gov/pubmed/18978791
http://dx.doi.org/10.1038/ng.250

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