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Single-chain Fv phage display propensity exhibits strong positive correlation with overall expression levels
BACKGROUND: Single chain Fvs (scFvs) are widely applied in research, diagnostics and therapeutic settings. Display and selection from combinatorial libraries is the main route to their discovery and many factors influence the success of this process. They exhibit low thermodynamic stability, resulti...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2630973/ https://www.ncbi.nlm.nih.gov/pubmed/19113995 http://dx.doi.org/10.1186/1472-6750-8-97 |