Impact of low-frequency hotspot mutation R282Q on the structure of p53 DNA-binding domain as revealed by crystallography at 1.54 Å resolution

Tumor suppressor p53 is a sequence-specific DNA-binding protein and its central DNA-binding domain (DBD) harbors six hotspots (Arg175, Gly245, Arg248, Arg249, Arg273 and Arg282) for human cancers. Here, the crystal structure of a low-frequency hotspot mutant, p53DBD(R282Q), is reported at 1.54 Å res...

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Detalles Bibliográficos
Autores principales: Tu, Chao, Tan, Yu-Hong, Shaw, Gary, Zhou, Zheng, Bai, Yawen, Luo, Ray, Ji, Xinhua
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2008
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2631104/
https://www.ncbi.nlm.nih.gov/pubmed/18453682
http://dx.doi.org/10.1107/S0907444908003338

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2631104/
https://www.ncbi.nlm.nih.gov/pubmed/18453682
http://dx.doi.org/10.1107/S0907444908003338

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