Chronic, low-dose rotenone reproduces Lewy neurites found in early stages of Parkinson's disease, reduces mitochondrial movement and slowly kills differentiated SH-SY5Y neural cells

BACKGROUND: Parkinson's disease, the most common adult neurodegenerative movement disorder, demonstrates a brain-wide pathology that begins pre-clinically with alpha-synuclein aggregates ("Lewy neurites") in processes of gut enteric and vagal motor neurons. Rostral progression into su...

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Detalles Bibliográficos
Autores principales: Borland, M Kathleen, Trimmer, Patricia A, Rubinstein, Jeremy D, Keeney, Paula M, Mohanakumar, KP, Liu, Lei, Bennett, James P
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2631511/
https://www.ncbi.nlm.nih.gov/pubmed/19114014
http://dx.doi.org/10.1186/1750-1326-3-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2631511/
https://www.ncbi.nlm.nih.gov/pubmed/19114014
http://dx.doi.org/10.1186/1750-1326-3-21

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