Cargando…
Chronic, low-dose rotenone reproduces Lewy neurites found in early stages of Parkinson's disease, reduces mitochondrial movement and slowly kills differentiated SH-SY5Y neural cells
BACKGROUND: Parkinson's disease, the most common adult neurodegenerative movement disorder, demonstrates a brain-wide pathology that begins pre-clinically with alpha-synuclein aggregates ("Lewy neurites") in processes of gut enteric and vagal motor neurons. Rostral progression into su...
Autores principales: | Borland, M Kathleen, Trimmer, Patricia A, Rubinstein, Jeremy D, Keeney, Paula M, Mohanakumar, KP, Liu, Lei, Bennett, James P |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2008
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2631511/ https://www.ncbi.nlm.nih.gov/pubmed/19114014 http://dx.doi.org/10.1186/1750-1326-3-21 |
Ejemplares similares
-
Baicalein antagonizes rotenone-induced apoptosis in dopaminergic SH-SY5Y cells related to Parkinsonism
por: Song, Ju-Xian, et al.
Publicado: (2012) -
Differential Effects of Methyl-4-Phenylpyridinium Ion, Rotenone, and Paraquat on Differentiated SH-SY5Y Cells
por: Martins, João Barbosa, et al.
Publicado: (2013) -
Hepcidin Decreases Rotenone-Induced α-Synuclein Accumulation via Autophagy in SH-SY5Y Cells
por: Li, Meiqi, et al.
Publicado: (2020) -
Ndfip1 Prevents Rotenone-Induced Neurotoxicity and Upregulation of α-Synuclein in SH-SY5Y Cells
por: Liu, Xin, et al.
Publicado: (2021) -
Over-expression of survivin could prevent the oxidative stress and toxicity of rotenone in SH-SY5Y cells
por: Rahimmi, Arman, et al.
Publicado: (2022)