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Rat Urinary Bladder Carcinogenesis by Dual-Acting PPARα + γ Agonists
Despite clinical promise, dual-acting activators of PPARα and γ (here termed PPARα+γ agonists) have experienced high attrition rates in preclinical and early clinical development, due to toxicity. In some cases, discontinuation was due to carcinogenic effect in the rat urothelium, the epithelial lay...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Hindawi Publishing Corporation
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2632771/ https://www.ncbi.nlm.nih.gov/pubmed/19197366 http://dx.doi.org/10.1155/2008/103167 |