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Chemical synthesis of oligodeoxyribonucleotides containing N3- and O(4)-carboxymethylthymidine and their formation in DNA
Humans are exposed to N-nitroso compounds from both endogenous and exogenous sources. Many N-nitroso compounds can be metabolically activated to give diazoacetate, which can result in the carboxymethylation of DNA. The remarkable similarity in p53 mutations found in human gastrointestinal tumors and...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2632895/ https://www.ncbi.nlm.nih.gov/pubmed/19042973 http://dx.doi.org/10.1093/nar/gkn946 |