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Chemical synthesis of oligodeoxyribonucleotides containing N3- and O(4)-carboxymethylthymidine and their formation in DNA

Humans are exposed to N-nitroso compounds from both endogenous and exogenous sources. Many N-nitroso compounds can be metabolically activated to give diazoacetate, which can result in the carboxymethylation of DNA. The remarkable similarity in p53 mutations found in human gastrointestinal tumors and...

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Detalles Bibliográficos
Autores principales:	Wang, Jianshuang, Wang, Yinsheng
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2009
Materias:	Chemistry and Synthetic Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2632895/ https://www.ncbi.nlm.nih.gov/pubmed/19042973 http://dx.doi.org/10.1093/nar/gkn946

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