DNA damage alters DNA polymerase δ to a form that exhibits increased discrimination against modified template bases and mismatched primers

Human DNA polymerase δ (Pol δ4), a key enzyme in chromosomal replication, is a heterotetramer composed of the p125, p50, p68 and p12 subunits. Genotoxic agents such as UV and alkylating chemicals trigger a DNA damage response in which Pol δ4 is converted to a trimer (Pol δ3) by degradation of p12. W...

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Detalles Bibliográficos
Autores principales: Meng, Xiao, Zhou, Yajing, Zhang, Sufang, Lee, Ernest Y. C., Frick, David N., Lee, Marietta Y. W. T.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2632934/
https://www.ncbi.nlm.nih.gov/pubmed/19074196
http://dx.doi.org/10.1093/nar/gkn1000

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2632934/
https://www.ncbi.nlm.nih.gov/pubmed/19074196
http://dx.doi.org/10.1093/nar/gkn1000

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