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DNA damage alters DNA polymerase δ to a form that exhibits increased discrimination against modified template bases and mismatched primers
Human DNA polymerase δ (Pol δ4), a key enzyme in chromosomal replication, is a heterotetramer composed of the p125, p50, p68 and p12 subunits. Genotoxic agents such as UV and alkylating chemicals trigger a DNA damage response in which Pol δ4 is converted to a trimer (Pol δ3) by degradation of p12. W...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2632934/ https://www.ncbi.nlm.nih.gov/pubmed/19074196 http://dx.doi.org/10.1093/nar/gkn1000 |