Attenuation of Zinc Finger Nuclease Toxicity by Small-Molecule Regulation of Protein Levels

Zinc finger nucleases (ZFNs) have been used successfully to create genome-specific double-strand breaks and thereby stimulate gene targeting by several thousand fold. ZFNs are chimeric proteins composed of a specific DNA-binding domain linked to a non-specific DNA-cleavage domain. By changing key re...

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Detalles Bibliográficos
Autores principales: Pruett-Miller, Shondra M., Reading, David W., Porter, Shaina N., Porteus, Matthew H.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2633050/
https://www.ncbi.nlm.nih.gov/pubmed/19214211
http://dx.doi.org/10.1371/journal.pgen.1000376

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2633050/
https://www.ncbi.nlm.nih.gov/pubmed/19214211
http://dx.doi.org/10.1371/journal.pgen.1000376

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