Disruption of the EGFR E884-R958 ion pair conserved in the human kinome differentially alters signaling and inhibitor sensitivity

Targeted therapy against epidermal growth factor receptor (EGFR) represents a major therapeutic advance in lung cancer treatment. Somatic mutations of the EGFR gene, most commonly L858R (exon 21) and short in-frame exon 19 deletions, have been found to confer enhanced sensitivity towards the inhibit...

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Detalles Bibliográficos
Autores principales: Tang, Zhe, Jiang, Shan, Du, Runlei, Petri, Edward T., El-Telbany, Ahmed, Chan, Perry S.O., Kijima, Takashi, Dietrich, Sascha, Matsui, Kaoru, Kobayashi, Masashi, Sasada, Shinji, Okamoto, Norio, Suzuki, Hideaki, Kawahara, Kunimitsu, Iwasaki, Teruo, Nakagawa, Katsuhiro, Kawase, Ichiro, Christensen, James G., Hirashima, Tomonori, Halmos, Balazs, Salgia, Ravi, Boggon, Titus J., Kern, Jeffrey A., Ma, Patrick C.
Formato: Texto
Lenguaje:English
Publicado: 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2633425/
https://www.ncbi.nlm.nih.gov/pubmed/19015641
http://dx.doi.org/10.1038/onc.2008.411

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2633425/
https://www.ncbi.nlm.nih.gov/pubmed/19015641
http://dx.doi.org/10.1038/onc.2008.411

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