Temozolomide- and fotemustine-induced apoptosis in human malignant melanoma cells: response related to MGMT, MMR, DSBs, and p53

Malignant melanomas are highly resistant to chemotherapy. First-line chemotherapeutics used in melanoma therapy are the methylating agents dacarbazine (DTIC) and temozolomide (TMZ) and the chloroethylating agents BCNU and fotemustine. Here, we determined the mode of cell death in 11 melanoma cell li...

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Detalles Bibliográficos
Autores principales: Naumann, S C, Roos, W P, Jöst, E, Belohlavek, C, Lennerz, V, Schmidt, C W, Christmann, M, Kaina, B
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2009
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2634706/
https://www.ncbi.nlm.nih.gov/pubmed/19127257
http://dx.doi.org/10.1038/sj.bjc.6604856

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2634706/
https://www.ncbi.nlm.nih.gov/pubmed/19127257
http://dx.doi.org/10.1038/sj.bjc.6604856

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