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Oscillations of the p53-Akt Network: Implications on Cell Survival and Death
Intracellular protein levels of p53 and MDM2 have been shown to oscillate in response to ionizing radiation (IR), but the physiological significance of these oscillations remains unclear. The p53-MDM2 negative feedback loop – the putative cause of the oscillations – is embedded in a network involvin...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2634840/ https://www.ncbi.nlm.nih.gov/pubmed/19197384 http://dx.doi.org/10.1371/journal.pone.0004407 |