The function of APC/C(Cdh1 )in cell cycle and beyond

The anaphase promoting complex/cyclosome (APC/C) is a multi-subunit E3 ubiquitin ligase playing essential functions in mitosis. It is conserved from yeast to human and relies on two adaptor proteins, Cdc20 and Cdh1, to bring in substrates. Both APC(Cdc20 )and APC(Cdh1 )are implicated in the control...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Min, Zhang, Pumin
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2635356/
https://www.ncbi.nlm.nih.gov/pubmed/19152694
http://dx.doi.org/10.1186/1747-1028-4-2
Descripción
Sumario:The anaphase promoting complex/cyclosome (APC/C) is a multi-subunit E3 ubiquitin ligase playing essential functions in mitosis. It is conserved from yeast to human and relies on two adaptor proteins, Cdc20 and Cdh1, to bring in substrates. Both APC(Cdc20 )and APC(Cdh1 )are implicated in the control of mitosis through mediating ubiquitination and degradation of important mitotic regulators such as cyclin B1, securin, and Plk1. In addition, APC(Cdh1 )is thought to prevent premature S phase entry by limiting the accumulation of mitotic cyclins in G1 and to regulate processes unrelated to cell cycle. In this review, we will summarize our current understanding of APC(Cdh1 )function in cell cycle and beyond.

Ejemplares similares