The function of APC/C(Cdh1 )in cell cycle and beyond

The anaphase promoting complex/cyclosome (APC/C) is a multi-subunit E3 ubiquitin ligase playing essential functions in mitosis. It is conserved from yeast to human and relies on two adaptor proteins, Cdc20 and Cdh1, to bring in substrates. Both APC(Cdc20 )and APC(Cdh1 )are implicated in the control...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Min, Zhang, Pumin
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2635356/
https://www.ncbi.nlm.nih.gov/pubmed/19152694
http://dx.doi.org/10.1186/1747-1028-4-2
_version_ 1782164175053651968
author Li, Min
Zhang, Pumin
author_facet Li, Min
Zhang, Pumin
author_sort Li, Min
collection PubMed
description The anaphase promoting complex/cyclosome (APC/C) is a multi-subunit E3 ubiquitin ligase playing essential functions in mitosis. It is conserved from yeast to human and relies on two adaptor proteins, Cdc20 and Cdh1, to bring in substrates. Both APC(Cdc20 )and APC(Cdh1 )are implicated in the control of mitosis through mediating ubiquitination and degradation of important mitotic regulators such as cyclin B1, securin, and Plk1. In addition, APC(Cdh1 )is thought to prevent premature S phase entry by limiting the accumulation of mitotic cyclins in G1 and to regulate processes unrelated to cell cycle. In this review, we will summarize our current understanding of APC(Cdh1 )function in cell cycle and beyond.
format Text
id pubmed-2635356
institution National Center for Biotechnology Information
language English
publishDate 2009
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-26353562009-02-04 The function of APC/C(Cdh1 )in cell cycle and beyond Li, Min Zhang, Pumin Cell Div Review The anaphase promoting complex/cyclosome (APC/C) is a multi-subunit E3 ubiquitin ligase playing essential functions in mitosis. It is conserved from yeast to human and relies on two adaptor proteins, Cdc20 and Cdh1, to bring in substrates. Both APC(Cdc20 )and APC(Cdh1 )are implicated in the control of mitosis through mediating ubiquitination and degradation of important mitotic regulators such as cyclin B1, securin, and Plk1. In addition, APC(Cdh1 )is thought to prevent premature S phase entry by limiting the accumulation of mitotic cyclins in G1 and to regulate processes unrelated to cell cycle. In this review, we will summarize our current understanding of APC(Cdh1 )function in cell cycle and beyond. BioMed Central 2009-01-19 /pmc/articles/PMC2635356/ /pubmed/19152694 http://dx.doi.org/10.1186/1747-1028-4-2 Text en Copyright © 2009 Li and Zhang; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Li, Min
Zhang, Pumin
The function of APC/C(Cdh1 )in cell cycle and beyond
title The function of APC/C(Cdh1 )in cell cycle and beyond
title_full The function of APC/C(Cdh1 )in cell cycle and beyond
title_fullStr The function of APC/C(Cdh1 )in cell cycle and beyond
title_full_unstemmed The function of APC/C(Cdh1 )in cell cycle and beyond
title_short The function of APC/C(Cdh1 )in cell cycle and beyond
title_sort function of apc/c(cdh1 )in cell cycle and beyond
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2635356/
https://www.ncbi.nlm.nih.gov/pubmed/19152694
http://dx.doi.org/10.1186/1747-1028-4-2
work_keys_str_mv AT limin thefunctionofapcccdh1incellcycleandbeyond
AT zhangpumin thefunctionofapcccdh1incellcycleandbeyond
AT limin functionofapcccdh1incellcycleandbeyond
AT zhangpumin functionofapcccdh1incellcycleandbeyond

Ejemplares similares