Silencing the cochaperone CDC37 destabilises kinase clients and sensitises cancer cells to HSP90 inhibitors

The cochaperone CDC37 promotes association of HSP90 with the protein kinase subset of client proteins to maintain their stability and signalling functions. HSP90 inhibitors induce depletion of clients, which include several oncogenic kinases. We hypothesised that the targeting of CDC37 using siRNAs...

Descripción completa

Detalles Bibliográficos
Autores principales: Smith, Jennifer R., Clarke, Paul A., de Billy, Emmanuel, Workman, Paul
Formato: Texto
Lenguaje:English
Publicado: 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2635547/
https://www.ncbi.nlm.nih.gov/pubmed/18931700
http://dx.doi.org/10.1038/onc.2008.380

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2635547/
https://www.ncbi.nlm.nih.gov/pubmed/18931700
http://dx.doi.org/10.1038/onc.2008.380

Ejemplares similares