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Substituting N(ε)-thioacetyl-lysine for N(ε)-acetyl-lysine in Peptide Substrates as a General Approach to Inhibiting Human NAD(+)-dependent Protein Deacetylases
Inhibitors of human NAD(+)-dependent protein deacetylases possess great value for deciphering the biology of these enzymes and as potential therapeutics for metabolic and age-related diseases and cancer. In the current study, we have experimentally demonstrated that, the potent inhibition we obtaine...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Molecular Diversity Preservation International (MDPI)
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2635597/ https://www.ncbi.nlm.nih.gov/pubmed/19325715 |