Conserved retinoblastoma protein-binding motif in human cytomegalovirus UL97 kinase minimally impacts viral replication but affects susceptibility to maribavir

The UL97 kinase has been shown to phosphorylate and inactivate the retinoblastoma protein (Rb) and has three consensus Rb-binding motifs that might contribute to this activity. Recombinant viruses containing mutations in the Rb-binding motifs generally replicated well in human foreskin fibroblasts w...

Descripción completa

Detalles Bibliográficos
Autores principales: Gill, Rachel B, Frederick, Samuel L, Hartline, Caroll B, Chou, Sunwen, Prichard, Mark N
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2636770/
https://www.ncbi.nlm.nih.gov/pubmed/19159461
http://dx.doi.org/10.1186/1743-422X-6-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2636770/
https://www.ncbi.nlm.nih.gov/pubmed/19159461
http://dx.doi.org/10.1186/1743-422X-6-9

Ejemplares similares