Quantification of gamma-secretase modulation differentiates inhibitor compound selectivity between two substrates Notch and amyloid precursor protein

BACKGROUND: Deposition of amyloid-β protein (Aβ) is a major pathological hallmark of Alzheimer's disease (AD). Aβ is generated from γ-secretase cleavage of amyloid precursor protein (APP). In addition to APP, γ-secretase also cleaves other type I integral membrane proteins, including the Notch...

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Detalles Bibliográficos
Autores principales: Yang, Ting, Arslanova, Dilyara, Gu, Yongli, Augelli-Szafran, Corinne, Xia, Weiming
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637266/
https://www.ncbi.nlm.nih.gov/pubmed/18983676
http://dx.doi.org/10.1186/1756-6606-1-15

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637266/
https://www.ncbi.nlm.nih.gov/pubmed/18983676
http://dx.doi.org/10.1186/1756-6606-1-15

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