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Quantification of gamma-secretase modulation differentiates inhibitor compound selectivity between two substrates Notch and amyloid precursor protein

BACKGROUND: Deposition of amyloid-β protein (Aβ) is a major pathological hallmark of Alzheimer's disease (AD). Aβ is generated from γ-secretase cleavage of amyloid precursor protein (APP). In addition to APP, γ-secretase also cleaves other type I integral membrane proteins, including the Notch...

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Detalles Bibliográficos
Autores principales:	Yang, Ting, Arslanova, Dilyara, Gu, Yongli, Augelli-Szafran, Corinne, Xia, Weiming
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2008
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637266/ https://www.ncbi.nlm.nih.gov/pubmed/18983676 http://dx.doi.org/10.1186/1756-6606-1-15

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