Imprinted CDKN1C Is a Tumor Suppressor in Rhabdoid Tumor and Activated by Restoration of SMARCB1 and Histone Deacetylase Inhibitors

SMARCB1 is deleted in rhabdoid tumor, an aggressive paediatric malignancy affecting the kidney and CNS. We hypothesized that the oncogenic pathway in rhabdoid tumors involved epigenetic silencing of key cell cycle regulators as a consequence of altered chromatin-remodelling, attributable to loss of...

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Detalles Bibliográficos
Autores principales: Algar, Elizabeth M., Muscat, Andrea, Dagar, Vinod, Rickert, Christian, Chow, C. W., Biegel, Jaclyn A., Ekert, Paul G., Saffery, Richard, Craig, Jeff, Johnstone, Ricky W., Ashley, David M.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637419/
https://www.ncbi.nlm.nih.gov/pubmed/19221586
http://dx.doi.org/10.1371/journal.pone.0004482

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637419/
https://www.ncbi.nlm.nih.gov/pubmed/19221586
http://dx.doi.org/10.1371/journal.pone.0004482

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