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Imprinted CDKN1C Is a Tumor Suppressor in Rhabdoid Tumor and Activated by Restoration of SMARCB1 and Histone Deacetylase Inhibitors
SMARCB1 is deleted in rhabdoid tumor, an aggressive paediatric malignancy affecting the kidney and CNS. We hypothesized that the oncogenic pathway in rhabdoid tumors involved epigenetic silencing of key cell cycle regulators as a consequence of altered chromatin-remodelling, attributable to loss of...
Autores principales: | Algar, Elizabeth M., Muscat, Andrea, Dagar, Vinod, Rickert, Christian, Chow, C. W., Biegel, Jaclyn A., Ekert, Paul G., Saffery, Richard, Craig, Jeff, Johnstone, Ricky W., Ashley, David M. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637419/ https://www.ncbi.nlm.nih.gov/pubmed/19221586 http://dx.doi.org/10.1371/journal.pone.0004482 |
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